Prostate cancer is the second only to the lung tumor in men worldwide, with about 900 000 new cases diagnosed annually and more than 250 000 deaths a year.
What causes the development of prostate cancer?
Genetic errors in the genes regulating cell growth and DNA repair play a principal role in the development of prostate cancer.
The genes BRCA1 and BRCA2 are the DNA repair genes and exist in the genome of man as well as a woman. Normally these genes repair errors or mutations occurring in the structure of the DNA molecule. However, when they cannot operate properly due to the modifications in their own structure, the cell looks like a shop full of working machines but without a mechanic. With time more and more machines get out of the order. BRCA functional loss results in genomic instability and the accumulation of genetic errors in cells. So we get these genes from our parents, regardless they are normal or mutated.