For over 75 years, it has been accepted that higher serum testosterone increases the risk of developing both new and rapid growth of latent prostate cancer. How did it happen that testosterone, being a hormone controlling the development of the prostate early in life, becomes a destruction and degeneration factor of the prostate in old age? What is the price of risk of testosterone therapy and does it prove the expected benefits? There is considerable evidence that androgen deprivation therapy noticeably depresses the development of prostate cancer in humans and prostate cell line experimental systems. However, there is no clear evidence that an increase in endogenous testosterone levels contributes to the development of prostate cancer in men.
Let’s study the issue carefully analyzing the pros and cons of available evidence-based data.