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Prostate cancer

Prostate cancer prevention, diagnosis and treatment.

National Cancer Institute| Healthy Prostate

Unlocking the Mysteries of Prostate Cancer: Cutting-Edge Research and Therapies

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Prostate cancer, a formidable adversary impacting the lives of millions of men worldwide, remains one of the most commonly diagnosed cancers. It occurs when abnormal cells develop in the prostate gland, a vital part of the male reproductive system. While many prostate cancer cases progress slowly, some can be aggressive and life-threatening. Timely detection and effective treatment are crucial to improving patient outcomes and quality of life.

This blog post delves into the fascinating world of cutting-edge prostate cancer research and therapies. Join us as we explore innovative diagnostic tools, groundbreaking treatment options, and the exciting potential of personalized medicine, all while keeping a keen eye on the horizon for the next revolutionary breakthrough. Together, let us unlock the mysteries of prostate cancer and embrace a future where this disease meets its match.

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sunbathing kid| Healthy Prostate

Vitamin D3 and Prostate Health

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Vitamin D3, or cholecalciferol, is the most vital steroid in the group of vitamin D, crucial to numerous bodily functions. It contributes to multiple aspects of men’s well-being.

Effects of vitamin D3 on overall health:

  1. Bone health: Vitamin D3 promotes calcium absorption and phosphorus regulation, which is vital for maintaining strong bones and preventing conditions like osteoporosis and rickets.
  2. Immune function: Vitamin D3 strengthens the immune system, helping the body fight infections and reducing inflammation.
  3. Cardiovascular health: Adequate vitamin D3 is associated with better cardiovascular health and reduced risk of heart diseases.
  4. Mental health: Vitamin D3 has been linked to improved mood, cognitive function, and reduced risk of depression.
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Man Destroing DNA| Healthy Prostate

The Larger Your Prostate, the Less Your Chance of Getting Prostate Cancer

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Until recently, the relationship betweenbenign prostate hyperplasia(BPH) and prostate cancer (PC) remained controversial. Some studies have found such a relationship, while others, on the contrary, could not find any association between them. Therefore, the idea of the independence of these prostate conditions has been propagated to reduce the fear of most people suffering from BPH symptoms of a possible escalation into PC. The larger your prostate, the less your chance of getting prostate cancer – this is the main conclusion of the recent study by K. R. Nandalur et al.(2021).

The results of a recent study published in “The Prostate” not only resolve these inconsistencies but, most importantly, confirm a significant inverse relationship between prostate size and the risk of PC. In the post, we will discuss this study, the results of which others will hopefully confirm.

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broccoli-sprouts| Healthy Prostate

Cruciferous Vegetables (Sulforaphane) and Prostate Cancer: A Comprehensive Analysis


Prostate cancer (PC) is a disease typically associated with old age, although anomalies in the prostate tissue can be observed in men as young as their twenties or thirties. PC is generally considered to be slow-growing cancer. The long, relatively silent period of prostate cancer suggests that various therapies could potentially slow disease progression or prevent disease onset, thereby reducing or eliminating the need for invasive surgical procedures such as prostatectomy.

In the previous posts, we discussed various food ingredients such asLycopene in tomatoes, Polyacetylenic oxylipins in carrots, Vitamin K2 in sauerkraut, and nattothat have proven anti-cancer activities. This article will address the potential cancer-fighting properties of another natural gift – broccoli.

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Foods Reducing the Risk of Prostate Cancer. Tomatoes

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Lycopene, a member of the carotenoid family, is generously found in tomatoes and tomato-based products, pink grapefruit, and watermelon. Interestingly, despite their lack of red or orange color, asparagus, and parsley are also substantial sources of lycopene.

As a potent antioxidant, lycopene is vital in neutralizing reactive oxygen species. The human body, however, cannot synthesize lycopene alone; it must be supplied through our daily diet. Once absorbed, lycopene is primarily stored in the testes, liver, adrenal glands, and prostate. Its concentration in the testes is up to ten times higher than in other tissues, suggesting a unique biological role in these areas.

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couple holding hands| Healthy Prostate

The Relationship Between Sexual Activity and Prostate Cancer Risk

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Engaging in sexual activity, especially beyond the age of 50, is a key aspect of overall well-being and quality of life, particularly for individuals with an active lifestyle. Despite the general decline in libido with age, approximately 40% of married men over 60 remain sexually active, engaging in sexual activities between 1 and 4 times per month. Given that the prostate gland plays a crucial role in reproduction and semen formation – contributing around 30% of its volume – it’s reasonable to assume that the health of this gland might be influenced by sexual activity. Moreover, since the risk of prostate cancer escalates with age, researchers have long been interested in the potential correlation between prostate cancer risk and ejaculation frequency or prostate activity.

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Prostate cancer: the role of estrogen

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Despite the general belief that higher serum testosterone increases the risk of developing new and rapid growth of latent prostate cancer (PC), recently, some scientists have attributed testosterone only a secondary role. And the emphasis is being shifted onto its direct derivative-estradiol.

The enzyme aromatase converts about 0.3-0.4 % of testosterone (T) into estradiol (E2) in a man’s body. Probably, the labeling of these compounds as the male’s and the female’s hormones allowed E2 to stay in the shade, while the high T content and its well-known anabolic properties attracted much more attention regarding malignant cell growth. Moreover, for the last eight decades, evidence has directly pointed to T in fuelling prostate cancer.

This belief has resulted in fear of T therapy for cancer patients and all kinds of men suffering from low T. Evidence-based education of the general public about the true relationship between T, E2, and PC may help change public consciousness and facilitate future progress in this demanding area. Let’s try to analyze the available data and understand how these two hormones affect the development of prostate cancer.

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Testosterone and prostate health

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For over 75 years, it has been accepted that higher serum testosterone increases the risk of developing both new and rapid growth of latent prostate cancer. How did it happen that testosterone, being a hormone controlling the development of the prostate early in life, becomes a destruction and degeneration factor of the prostate in old age? What is the price of risk of testosterone therapy, and does it prove the expected benefits? There is considerable evidence that androgen deprivation therapy noticeably depresses the development of prostate cancer in humans and prostate cell line experimental systems. However, there is no clear evidence that an increase in endogenous testosterone levels contributes to the development of prostate cancer in men.
Let’s study the issue carefully, analyzing the pros and cons of available evidence-based data.

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Prostate-specific antigen (PSA)


PSA is an organ-specific enzyme produced by epithelial cells of the prostate. In healthy men, most PSA is secreted into seminal fluid liquifying semen, and only a small amount of it leaks into circulation. Normal PSA levels in the blood amount between 0-2.5 ng/ml. As a man ages, his prostate gets larger, leading to slightly higher normal levels of PSA.

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