Despite the general belief that higher serum testosterone increases the risk of developing new and rapid growth of latent prostate cancer (PC), recently some scientists attribute testosterone only a secondary role. And the emphasis is being shifted onto its direct derivative-estradiol.
In a man’s body, enzyme aromatase converts about 0.3-0.4 % of testosterone into estradiol. Probably, the labeling of these compounds as the male’s and the female’s hormones allowed estradiol to stay in the shade while the high testosterone content and its well-known anabolic properties attracted much more attention regarding malignant cell growth. Moreover, for the last eight decades, there has been accumulating evidence directly pointing to T in fuelling prostate cancer.
This belief has resulted in a fear of testosterone therapy for both cancer patients and all kinds of men suffering from low testosterone. Evidence-based education of the general public about the true relationship between testosterone, estradiol, and PC may help to change public consciousness and facilitate future progress in this demanding area. Let’s try to analyze the available data and understand how these two hormones affect the development of prostate cancer.Read More