Unlike most hormones, prostaglandins are not produced by glands but rather at the location that they are needed. Prostaglandins are part of the body’s response to stress and injury. They help create inflammation and are also potentially pro-cancer. Aspirin reduces prostaglandin production (via COX-1 and COX-2 inhibition). Naproxen also reduces prostaglandins through similar mechanisms. Curcumin selectively inhibits COX-2 and might be a safer way to reduce prostaglandins than aspirin or naproxen. However, the substance has not been studied as extensively as aspirin or naproxen. It is also not as tightly regulated. Prostaglandin reduction can be good but must not be overdone. Some inflammation is necessary to heal wounds.