Healthspan & Longevity Intelligence System

Understand your healthspan reserve. See what is strong, what deserves attention, and which changes have the best evidence for supporting healthy aging.

Enter ordinary health and performance data. The system separates disease-risk control, physical reserve, and intrinsic capacity without producing a misleading “biological age.”

Public UX • v1.6.1
Privacy: your entries stay in this browser on this device and are not transmitted anywhere by this prototype. Clinical flags remain separate from healthspan scores and cannot be averaged away.

Start with what you know

Complete the short first step and see useful results immediately. Add labs or performance measurements later only if you want more precision.

1

Start simple

Basic health context, blood pressure, activity, strength training, smoking, and sleep. About 3 minutes.

2

See your profile

Get preliminary disease-risk control and physical-reserve results. Missing information is shown as uncertainty—not as poor health.

3

Improve precision

Add bloodwork, VO₂max, grip strength, mobility tests, bone, cognition, sensory, or social information whenever you have it.

One full engine, progressive depth. Skipping an optional section does not lower your score. It only lowers confidence in the affected domain.

Quick Assessment

About 3 minutes. Answer what you know; leave anything else blank.

Quick-assessment progress0 of 12 core items
You can open preliminary results before reaching 100%.
About you
Health context
These three questions prevent the engine from applying healthy-person rules to someone who already has a diagnosed condition.
Blood pressure & lifestyle
Examples: brisk walking, comfortable cycling.
Examples: running, hard cycling, vigorous swimming.
Add more context (optional)

Improve Accuracy with Lab Results

Optional. Add only values you already know from recent blood or urine tests.

The four most useful entries here are usually LDL-C, HbA1c, eGFR, and UACR. Leave any unfamiliar field blank.
Usually listed as urine albumin-to-creatinine ratio. Skip if you have never had it measured.
Add advanced cardiovascular / metabolic data (optional)
Only enter a result obtained elsewhere; this tool does not calculate PREVENT internally.

Physical Reserve

Performance data outrank behavior proxies. VO₂max, grip strength, and five-chair-rise can now be translated automatically into age/sex reference percentiles when validated reference tables apply.

Aerobic reserve
FRIEND treadmill percentile lookup is available for ages 20–79. Cycle and out-of-range ages remain contextual rather than being forced into an inappropriate table.
Muscle & mobility
Automatic norming: grip strength uses iGRIPS international sex/age percentiles (20–100+); five-chair-rise uses pooled sex/age percentiles for adults 50+; TUG shows an age-context mean benchmark for adults 60+ while retaining the separate STEADI ≥12-second fall-risk screen. Screening thresholds and normative percentiles are displayed independently.

Complete Your Healthy-Aging Profile

Optional deeper assessment. Open only the areas you want to complete; your existing results remain valid if you stop here.

Sleep & recovery — Add sleep quality, awakenings, and possible apnea signals.
Sleep duration was collected in the Quick Assessment.Add sleep quality and breathing/fragmentation details here only if you want a fuller recovery profile.
Nutrition & body resilience — Add protein, dietary pattern, and unintentional weight change.
Bone & fracture resilience — Add DXA or fracture history if available.
Cognitive, sensory & social capacity — Short self-report signals; no biological-age or dementia prediction.

Your Healthspan Profile

No single longevity score. Important weaknesses remain visible even when other areas are strong.

Your profile is a map, not a grade.Strong areas stay visible, but an important weakness or clinical flag cannot be hidden by better results elsewhere.
Strong Good Opportunity Priority Major priority / clinical concern
Want more accuracy?Add recent labs you already know.
Measure reserve directlyAdd VO₂, grip, chair-rise, or mobility tests.
Go comprehensiveAdd sleep quality, nutrition, bone, cognition, sensory, and social context.
Clinical / safety flags
0
Major / priority domains
0
Core-data coverage
0%
BMI / waist-height ratio
What this profile means
Risk = contextual threats such as Lp(a), previous disease, or CAC.
Control = current modifiable disease-risk factors such as BP, LDL, glucose, and kidney markers.
Reserve = measured physiological capacity such as aerobic fitness, strength, mobility, and recovery.
Intrinsic capacity = cognition, sensory function, psychological/social resilience, and ability to do valued activities.
Assessment coverage by system
Peer Benchmarks

Direct peer comparisons are shown only where a validated reference is embedded. TUG remains an age-context benchmark rather than a percentile.

Assessment Audit Trail
Disease-risk control
Physical reserve
Intrinsic capacity & resilience

Data Worth Getting

Missing measurements are ranked by how much they would improve confidence—not treated as health deficits.

Your Recommendations

A short, prioritized guide to what deserves attention first—based on the information you entered.

Focus first
How these recommendations are chosen

Clinical issues come first. A finding that deserves medical follow-up cannot be pushed down the page by strong fitness, diet, or other good results.

Evidence matters. Strong guideline-supported actions rank above experimental longevity ideas.

Missing information is not a failure. It lowers confidence only.

No medication instructions. This tool never tells you to start, stop, or change prescription medication; those decisions are routed to clinician discussion.

Evidence key: A = strong guideline/intervention evidence; B = good human evidence/guideline support; C = useful but less certain evidence.

What If I Improve…?

Explore how a few realistic changes would alter your current healthspan profile. This is a hypothetical comparison—not a prediction of lifespan or biological age.

Your actual profile stays unchanged. The simulator creates a temporary copy of your current data, changes only the targets you choose, and recalculates the affected domains. Clinical alerts remain tied to your real entered values.
Choose changes to explore
Blood pressure
Current: —
Leave both blank to keep current BP unchanged.
LDL cholesterol
Current: —
Uses the same treatment-aware LDL scoring as the main engine.
Aerobic fitness
Current: —
When a valid age/sex reference is available, the same FRIEND percentile engine is used.
Strength training
Current: —
This changes the strength proxy only when direct grip/chair performance is not available.
Sleep
Current: —
Sleep above the usual 7–9 hour range is treated contextually rather than automatically rewarded or penalized.
Protein intake
Current: —
Generic higher-protein scoring is disabled when CKD, low eGFR, or albuminuria makes protein advice kidney-specific.
Waist circumference
Current: —
Body-composition context changes, but it does not dominate the healthspan profile.
Nicotine exposure
Current: —
This illustrates the profile effect of removing current exposure; it does not model how quickly risk falls after quitting.
Current vs simulated profile
Choose one or more target changes and click Simulate changes.
What changes most?
The simulator will highlight the domains with the largest modeled change.
The simulator recomputes the same profile rules used by the assessment. It does not estimate years of life gained, biological-age reversal, or the probability that a target will be achieved.

Why These Factors Matter

Healthy aging is not one biomarker, supplement, or “anti-aging” trick. It is the interaction of disease-risk control, physical reserve, recovery, and the ability to keep doing what matters to you.

The Longevity Pyramid

Higher layers can be interesting, but they should never substitute for an unresolved problem lower in the pyramid.

Optimization & ExperimentalTime-restricted eating, sauna, NAD+/NMN research, rapamycin, senolytics, epigenetic reprogramming
Functional ReserveVO₂max • strength • mobility • balance • cognition • sensory function • participation
Risk-Factor ControlBlood pressure • LDL/ApoB • glucose • kidney health • bone/fall risk • body composition
FoundationsNo tobacco • regular physical activity • resistance training • healthy diet • adequate sleep • meaningful social connection
How to read this pyramid: experimental longevity ideas may eventually become useful, but the human outcome evidence is much less mature than the evidence supporting physical activity, tobacco avoidance, cardiovascular-risk control, healthy sleep, and basic nutrition.
Evidence ladder used by this system
A
Strong

Guidelines and/or substantial human outcome evidence. These actions can drive core recommendations.

B
Good

Useful human evidence or strong professional guidance, but less definitive than Grade A.

C
Emerging

Promising or indirect evidence. May educate, but should not displace stronger actions.

Research
Experimental

Mechanistically interesting or early clinical research; not part of the core healthspan score.

Why each domain matters

Short explanations of what the dashboard is actually trying to protect.

❤️ Heart & Vessels

Blood pressure, atherogenic lipids, nicotine exposure, and established vascular disease shape the long-term risk of heart attack, stroke, heart failure, and vascular damage.

What matters most

Keep blood pressure and atherogenic cholesterol appropriately controlled and avoid tobacco/nicotine exposure.

Takeaway: Excellent fitness does not cancel uncontrolled hypertension or severe lipid risk.
Evidence AAHA/ACC cardiovascular prevention guidance; AHA Life’s Essential 8

🔬 Metabolic & Kidney Health

Glucose regulation and kidney function influence cardiovascular risk, energy metabolism, medication handling, and the ability to maintain health during aging.

What matters most

Use HbA1c or fasting glucose for metabolic context and interpret kidney filtration together with albuminuria—not eGFR alone.

Takeaway: Preserved eGFR does not completely rule out kidney risk when UACR is elevated.
Evidence AADA Standards of Care; KDIGO CKD framework

🫁 Aerobic Reserve

VO₂max reflects the integrated ability of the heart, lungs, circulation, and muscles to deliver and use oxygen during demanding activity.

What matters most

Regular aerobic activity builds capacity; direct VO₂ measurement tells us more about actual reserve than exercise minutes alone.

Takeaway: Activity is the behavior; cardiorespiratory fitness is the capacity produced by genetics, health, and training.
Evidence AHHS Physical Activity Guidelines; FRIEND fitness reference data

💪 Muscle & Strength

Strength supports independence, glucose disposal, mobility, recovery from illness, and the ability to keep performing daily tasks as reserve declines with age.

What matters most

Progressive resistance training plus adequate nutrition. Direct grip and chair-rise performance outrank simply reporting gym attendance.

Takeaway: Muscle size alone is not the goal—usable strength and function are.
Evidence AHHS physical-activity guidance; older-adult strength consensus

🚶 Mobility, Balance & Bone

Mobility and balance determine whether physical reserve can be used safely. Bone resilience matters because a single serious fracture can sharply reduce independence.

What matters most

Strength, balance practice, safe mobility, fall prevention, vision/footwear review when relevant, and appropriate bone assessment.

Takeaway: “I have not fallen” does not prove strong mobility reserve; direct testing adds important information.
Evidence ACDC STEADI; osteoporosis screening guidance

😴 Sleep & Recovery

Sleep supports cardiovascular, metabolic, immune, cognitive, and physical recovery. Older adults still generally need about 7–9 hours of sleep.

What matters most

Adequate opportunity, regular timing, restorative sleep, and evaluation when symptoms suggest a sleep disorder such as sleep apnea.

Takeaway: More time in bed is not always better; persistent unusually long sleep is interpreted in context rather than rewarded.
Evidence ANational Institute on Aging; AHA cardiovascular-health framework

🥗 Nutrition & Body Resilience

A healthy diet supports vascular, metabolic, gut, muscle, and bone health. In older adults, nutrition must also protect against loss of muscle and unintentional weight loss.

What matters most

Mostly minimally processed foods, plants and fiber-rich foods, appropriate protein, and enough energy to preserve function.

Takeaway: Lower weight is not automatically healthier, and generic high-protein advice should not override kidney-specific guidance.
Evidence A/BAHA/ADA dietary guidance; geriatric nutrition guidance; KDIGO when CKD is present

🧠👁️👂🤝 Intrinsic Capacity

Healthy aging is not just avoiding heart disease. Cognition, hearing, vision, psychological resilience, social connection, and the ability to participate in valued activities strongly affect independence.

What matters most

Recognize new functional decline, correct treatable sensory problems, maintain meaningful social participation, and seek formal assessment when concerning cognitive changes appear.

Takeaway: A perfect laboratory panel does not equal healthy aging if the person is becoming isolated, cognitively impaired, or unable to function independently.
Evidence A/BWHO healthy-aging framework; National Institute on Aging

Three influential longevity perspectives

These viewpoints can help readers understand the field. They do not determine the system’s score.

Peter Attia, MD

Preventive medicine / functional reserve

Attia strongly emphasizes cardiorespiratory fitness, strength, stability, metabolic health, and aggressive prevention of chronic disease.

His framework asks people to build enough reserve today to preserve the physical abilities they want in later decades.

How this system uses the idea: close alignment on VO₂max, strength, mobility, and risk-factor control. His personal training prescriptions are not treated as universal clinical guidelines.

Valter Longo, PhD

Gerontology / nutrition / fasting biology

Longo emphasizes plant-forward dietary patterns, nutrient-sensing pathways, avoidance of chronic overnutrition, and research on fasting and the fasting-mimicking diet (FMD).

His work highlights the tension between growth signaling earlier in life and preserving lean tissue and resilience later in life.

How this system uses the idea: strong agreement on food quality and avoiding chronic overnutrition. FMD and prolonged fasting remain outside the core score because human longevity-outcome evidence is less established and older adults must protect muscle.

David Sinclair, PhD

Molecular aging / NAD+ / epigenetics

Sinclair’s laboratory investigates cellular aging mechanisms including NAD+ biology, sirtuins, mitochondrial signaling, and epigenetic loss of cellular identity.

This research has helped make molecular aging interventions a major scientific field.

How this system uses the idea: scientifically interesting but intentionally separated from proven healthspan foundations. NAD+ boosters, NMN, and epigenetic reprogramming are not awarded core longevity points.
Evidence synthesis: the system is closest to mainstream preventive medicine on what users should do today: exercise, preserve strength, control cardiovascular/metabolic risk, sleep adequately, eat well, avoid tobacco, maintain function, and address medical problems. Expert-specific or experimental strategies are educational layers—not substitutes for those fundamentals.

Methodology & Implementation Status

Implemented in v0.5
Continuous blood-pressure status curves with severe-BP safety override.
Treatment-aware LDL and BP interpretation; treatment itself never reduces the score.
KDIGO-style joint eGFR × UACR classification rather than an invented kidney average.
Automatic FRIEND treadmill VO₂ percentile lookup for ages 20–79 using published percentile values.
Automatic iGRIPS handgrip percentile lookup for ages 20–100+ using sex- and 5-year-age-specific international norms.
Automatic five-chair-rise percentile lookup for adults 50+ using sex- and 5-year-age-specific pooled reference values from 45,470 adults in 14 European countries.
TUG age context uses published mean benchmarks for ages 60–99; it is intentionally not represented as a percentile. EWGSOP2 and CDC STEADI screening anchors remain separate clinical signals.
Local browser persistence, JSON export, demo personas, missing-data prioritization, and a no-global-score dashboard.
Longitudinal monitoring with dated local snapshots, raw-measure and domain trend charts, latest-vs-previous comparison, and deletion/export controls.
Measured, estimated, and contextual provenance cues are kept separate from health status and confidence.
Domain-specific coverage replaces crude form-completion percentages. High-value measurements count more than optional fields.
Peer Benchmarks show VO₂, grip, and chair-rise percentiles only where validated reference distributions are embedded; TUG remains an age-context mean benchmark.
A validation layer detects incompatible or misleading combinations without changing the underlying physiology score.
Validation hardening in v0.6: direct VO₂ is never replaced by an activity proxy when peer norming is unavailable; older-adult EWGSOP2/STEADI flags are age-gated; DXA T-score interpretation is sex/menopause aware; long sleep is contextual rather than automatically penalized; kidney risk disables generic high-protein scoring; severe triglycerides and low fasting glucose receive explicit clinical-context handling; and Heart & Vessels uses a weak-link cap to prevent major BP/lipid deficits from being averaged away.
Intentionally deferred
Unified CLSA age/sex percentile lookup for grip, chair rise, TUG, gait speed, and single-leg balance remains a future harmonization option. v0.6 uses newer international grip norms and a large pooled chair-rise reference set instead of waiting for one dataset to cover every function.
PREVENT calculation. v0.6 accepts only an externally obtained PREVENT result; it does not reverse-engineer or clone the AHA calculator.
Formal cognitive screening instrument, FRAX integration, recommendation library, and intervention simulator.
Public progressive UX v1.5
Final Mobile QA v1.5 adds touch-friendly 44px+ controls, a sticky horizontal phone navigation rail, automatic centering of the active section, readable stacked audit rows, phone-safe simulator comparisons, improved glossary controls, responsive charts, 390px/430px phone rules, and 768px tablet behavior. The scientific scoring and recommendation logic are unchanged.
Visual & Accessibility v1.4 increases secondary-text size and contrast, reduces border density, strengthens section hierarchy, improves mobile typography and keyboard focus, adds a status legend that does not rely on color alone, and uses reduced-motion preferences when requested by the user’s device.
Educational layer v1.3 adds the Longevity Pyramid, domain-specific “Why this matters” explanations, an evidence ladder, and clearly separated Attia/Longo/Sinclair perspectives. None of these educational views alter scoring.
Public action buttons use neutral styling unless they represent a true active state. This avoids the false impression that a button remains “selected” after other buttons are clicked.
Intervention Simulator v1.2 uses a temporary copy of the user’s current profile. It recomputes the validated profile rules for hypothetical targets without altering actual data or clinical alerts.
The simulator never estimates years of life gained, biological-age reversal, or the probability/time required to achieve a target.
A searchable public glossary is included after Methodology so technical abbreviations and scientific terms can be understood without leaving the tool.
Public navigation uses one primary system: the left-side journey. Global page-navigation buttons were removed from the header to avoid duplicated navigation and false active-state cues.
The public experience uses one full engine with progressive disclosure: Quick Assessment → preliminary results → optional labs → optional performance tests → optional comprehensive healthy-aging profile.
Missing optional data lower confidence/coverage only; they do not lower health status.
Conditional questions appear only when relevant, including severe-BP symptoms, diabetes medication, fall injury, menopausal status, and PREVENT compatibility.
Human-centered Recommendation Engine v1.4
Clinical-first lane: severe BP, diabetes-range screening results, severe dyslipidemia/hypertriglyceridemia, kidney-risk signals, fragility/osteoporosis context, falls, probable sleep-apnea signals, unexplained weight loss, and important cognitive-functional change.
Foundation lane: smoking cessation, aerobic activity/fitness, resistance training, BP-supportive diet/lifestyle, dietary quality, sleep, and context-appropriate protein adequacy.
Support lane: sensory assessment, social connection, and inherited-risk context such as elevated Lp(a).
Evidence library frozen August 2026: 2025 ACC/AHA High Blood Pressure Guideline; 2026 ACC/AHA Dyslipidemia Guideline; ADA Standards of Care 2026; KDIGO 2024 CKD Guideline; HHS Physical Activity Guidelines; CDC STEADI; NIA sleep/cognitive/sensory/social resources; USPSTF 2025 osteoporosis screening; ESPEN/PROT-AGE older-adult protein guidance.
Reference basis
ModulePrimary basisCurrent use
VO₂FRIEND treadmill CPET reference standardsAutomatic percentile, age 20–79
KidneyKDIGO GFR × albuminuria frameworkJoint risk stratum
Grip strengthiGRIPS / Tomkinson et al. 2025Automatic sex/age percentile + EWGSOP2 screening threshold
Chair riseGrgic et al. pooled FTSST normsAutomatic sex/age percentile + EWGSOP2 screening threshold
TUG / fallsBohannon age benchmarks + CDC STEADIAge-context benchmark + safety signals; no invented percentile
Unified functional normsCLSA / Mayhew et al.Future harmonization option

Glossary

Plain-language explanations of the medical, scientific, and technical terms used throughout the Healthspan & Longevity Intelligence System.

Tip: You do not need to learn these terms before using the assessment. Use this page whenever you encounter an unfamiliar abbreviation or concept.
74 terms
A

Actionability

How practical and realistic an action is for changing a health factor.

In this system: Used when the recommendation engine ranks what to address first.

Albuminuria

An abnormal amount of the protein albumin in urine. It can be a sign of kidney damage even when kidney filtration still looks normal.

In this system: Measured with UACR.

ApoB Apolipoprotein B

A protein found on atherogenic particles that can enter artery walls. ApoB is often used as an estimate of the number of cholesterol-carrying particles that can contribute to plaque.

In this system: Used as an advanced cardiovascular risk marker.

ASCVD Atherosclerotic Cardiovascular Disease

Heart and blood-vessel disease caused by plaque buildup in arteries, including heart attack, ischemic stroke, and peripheral artery disease.

In this system: Used to distinguish primary prevention from people who already have established cardiovascular disease.

Atherosclerosis

The buildup of cholesterol-rich plaque inside artery walls. Over time it can narrow arteries or trigger blood clots.

In this system: Central to cardiovascular-risk interpretation.
B

Biological age

An estimate of how old the body appears biologically rather than by calendar age. This system intentionally does not calculate a biological age because current methods can create misleading precision.

In this system: Not used as a score in this system.

Blood pressure BP

The force of blood against artery walls. It is reported as systolic pressure over diastolic pressure, for example 120/80 mmHg.

In this system: A major cardiovascular-control measure.

Body Mass Index BMI

Weight in kilograms divided by height in meters squared. BMI is a rough body-size measure and does not directly measure body fat or muscle.

In this system: Used only as supporting body-composition context.
C

CAC Coronary Artery Calcium score

A CT-based score that measures calcified plaque in the coronary arteries. A higher score usually indicates more coronary atherosclerosis.

In this system: Used as cardiovascular risk context rather than a lifestyle score.

Chair-rise test Five-chair-rise / 5×STS

A functional test that measures how quickly a person can stand up from a chair five times without using the arms if possible.

In this system: Used to assess lower-body strength and functional reserve.

CKD Chronic Kidney Disease

Persistent abnormalities in kidney structure or function, usually present for at least three months.

In this system: The system avoids diagnosing CKD from a single abnormal value.

Clinical flag

A result that may deserve medical attention and is kept separate from ordinary healthspan scoring.

In this system: Clinical flags cannot be averaged away by strong results in other domains.

Clinical-first action

A recommendation that deserves medical follow-up before lifestyle optimization or experimental longevity strategies.

In this system: Highest priority lane in the recommendation engine.

Confidence

How certain the system is about a result based on how much data are available and how directly the variable was measured.

In this system: A high-confidence measured result is more reliable than a questionnaire-based estimate.

Coverage

How much of the important information for a domain has been supplied.

In this system: Missing data lower coverage, not the health score.

CPET Cardiopulmonary Exercise Testing

A supervised exercise test that directly measures oxygen use, carbon dioxide production, breathing, and cardiovascular response during increasing effort.

In this system: The most direct method for measuring VO₂max or VO₂peak.
D

DASH Dietary Approaches to Stop Hypertension

An eating pattern rich in vegetables, fruits, whole grains, legumes, nuts, and appropriate low-fat foods, with lower sodium and limited highly processed foods.

In this system: A strongly supported dietary approach for blood-pressure control.

DBP Diastolic Blood Pressure

The lower blood-pressure number. It reflects arterial pressure while the heart relaxes between beats.

In this system: Used together with systolic blood pressure.

DXA Dual-energy X-ray Absorptiometry

A low-radiation scan commonly used to measure bone mineral density and help assess osteoporosis risk.

In this system: Used in the Bone & Fracture Resilience section.
E

eGFR Estimated Glomerular Filtration Rate

An estimate of how well the kidneys filter blood. It is usually calculated from blood creatinine plus age and sometimes other variables.

In this system: Interpreted together with UACR rather than alone.

Evidence grade

A simple label describing how strong the supporting evidence is. In this system, A is strongest, B is good human/guideline support, and C is more limited or indirect.

In this system: Shown on recommendations.

EWGSOP2 European Working Group on Sarcopenia in Older People 2

A European expert consensus framework for identifying and assessing sarcopenia, especially low muscle strength and function in older adults.

In this system: Provides screening anchors for grip strength and chair-rise performance.
F

Fasting glucose

Blood glucose measured after an overnight fast, typically at least 8 hours without caloric intake.

In this system: Used when HbA1c is unavailable or as additional metabolic context.

Fragility fracture

A fracture caused by a low level of trauma that would not normally break healthy bone, such as a fall from standing height.

In this system: An important signal of possible osteoporosis or increased fracture risk.

FRAX Fracture Risk Assessment Tool

A tool that estimates a person's 10-year probability of major osteoporotic fracture and hip fracture using clinical risk factors, sometimes with bone-density data.

In this system: Not currently embedded in the system because implementation/licensing needs to be handled separately.

FRIEND Fitness Registry and the Importance of Exercise National Database

A large reference database used to compare cardiorespiratory fitness values such as VO₂max across age and sex groups.

In this system: Used for VO₂max peer-percentile interpretation.
G

Grip strength

The maximum force produced when squeezing a hand dynamometer.

In this system: A practical measure of muscle strength and functional reserve.
H

HbA1c Hemoglobin A1c

A blood test that reflects average blood glucose exposure over roughly the previous 2–3 months.

In this system: Used for metabolic-health assessment and diabetes-range screening.

HDL-C High-Density Lipoprotein Cholesterol

The amount of cholesterol carried in HDL particles. HDL-C is part of standard lipid testing, but a higher value is not treated as a stand-alone longevity bonus.

In this system: Used mainly as cardiovascular context.

Health gap

The difference between a domain's current status and the system's high-reserve reference range.

In this system: Used internally when ranking recommendations.

Healthspan

The portion of life spent in good health and able to function independently, rather than simply the number of years lived.

In this system: The central outcome this system is designed around.
I

Intrinsic capacity

A World Health Organization concept describing the combined physical and mental capacities a person can draw on, including cognition, sensory function, psychological capacity, vitality, and locomotion.

In this system: Used to broaden the system beyond laboratory risk factors.
K

KDIGO Kidney Disease: Improving Global Outcomes

An international organization that publishes evidence-based guidelines for kidney disease.

In this system: Its eGFR × albuminuria framework is used in the kidney module.
L

LDL-C Low-Density Lipoprotein Cholesterol

The amount of cholesterol carried in LDL particles. Higher levels generally increase atherosclerotic cardiovascular risk.

In this system: A main cardiovascular-control variable.

Lean mass

Body mass that is not fat, including muscle, organs, water, and bone components.

In this system: Used only as supporting body-composition context because devices differ in accuracy.

Longevity

Length of life. Longevity is not identical to healthspan; living longer does not necessarily mean living longer in good function.

In this system: The system emphasizes healthspan and functional reserve rather than lifespan prediction.

Lp(a) Lipoprotein(a)

A cholesterol-carrying particle largely determined by genetics. High levels can raise cardiovascular risk independently of LDL-C.

In this system: Treated as an inherited risk enhancer, not as a lifestyle failure.
M

Metabolic health

How well the body regulates glucose, insulin-related processes, lipids, body composition, and energy balance.

In this system: Represented mainly through HbA1c/glucose and related context.

mmHg Millimeters of mercury

The standard unit used to report blood pressure.

In this system: For example, 120/80 mmHg.

Moderate-equivalent minutes

A way to combine moderate and vigorous exercise into one activity estimate. In this system, one vigorous minute counts approximately like two moderate minutes.

In this system: Used only when direct aerobic-fitness measurements are unavailable.
N

nmol/L Nanomoles per liter

A concentration unit used by some laboratories, including for Lp(a).

In this system: Lp(a) values in nmol/L are not automatically converted to mg/dL because the relationship is not fixed.

Non-HDL cholesterol Non-HDL-C

Total cholesterol minus HDL-C. It represents cholesterol carried by all potentially atherogenic particles.

In this system: Used as supporting cardiovascular context.
O

Osteopenia

A bone-density level lower than normal but not in the osteoporosis range when T-score criteria are appropriate.

In this system: May indicate increased fracture risk depending on the broader clinical context.

Osteoporosis

A condition of reduced bone strength that increases fracture risk. In appropriate populations, a DXA T-score of −2.5 or lower is in the osteoporosis range.

In this system: Bone interpretation depends on age, sex, menopausal status, fracture history, and other factors.
P

Percentile

A comparison with a reference population. For example, the 75th percentile means the result is higher or better than about 75% of the reference group when higher values indicate better performance.

In this system: Used for VO₂max, grip strength, and chair-rise reference comparisons where validated data are available.

PREVENT Predicting Risk of Cardiovascular Disease Events

An American Heart Association risk framework that estimates future cardiovascular risk in adults without established cardiovascular disease.

In this system: This system can accept an externally obtained PREVENT result but does not calculate it internally.

Primary prevention

Preventing a first cardiovascular event in a person who has not already had established atherosclerotic cardiovascular disease.

In this system: PREVENT applies to primary-prevention settings.

Protein g/kg/day

Daily protein intake expressed as grams of protein per kilogram of body weight per day.

In this system: Used to judge protein adequacy more fairly across different body sizes.
R

Reserve Physiological reserve

Extra functional capacity beyond what is needed for ordinary daily life. Higher reserve can help a person tolerate illness, injury, surgery, or aging-related stress.

In this system: A core concept behind Aerobic, Strength, and Mobility domains.

Resting heart rate RHR

Heart rate measured while resting and relaxed.

In this system: Used as supporting cardiovascular context rather than a dominant score.
S

Sarcopenia

Age-related loss of muscle strength and muscle quantity or quality that can impair physical function.

In this system: The system screens for low strength but does not diagnose sarcopenia.

SBP Systolic Blood Pressure

The upper blood-pressure number. It reflects arterial pressure when the heart contracts.

In this system: Used together with diastolic blood pressure.

Secondary prevention

Preventing additional cardiovascular events in someone who already has established cardiovascular disease.

In this system: Handled differently from primary prevention.

Sedentary time

Time spent sitting or otherwise awake with very low energy expenditure.

In this system: Used as lifestyle context; it does not replace direct fitness measurement.

STEADI Stopping Elderly Accidents, Deaths & Injuries

A CDC fall-prevention framework for screening and reducing fall risk in older adults.

In this system: Provides practical mobility and fall-risk screening anchors.
T

T-score

A bone-density result comparing a person's bone mineral density with that of a healthy young adult reference population.

In this system: Used mainly in postmenopausal women and men age 50 or older.

Triglycerides TG

A type of fat carried in the blood. Very high levels can raise pancreatitis risk and often reflect metabolic or dietary factors.

In this system: Used in cardiovascular/metabolic risk interpretation.

TUG Timed Up and Go

A mobility test in which a person stands from a chair, walks about 3 meters (10 feet), turns, walks back, and sits down while the total time is measured.

In this system: Used for mobility and fall-risk screening.
U

UACR Urine Albumin-to-Creatinine Ratio

A urine test that compares albumin with creatinine to detect abnormal leakage of protein through the kidneys.

In this system: Interpreted together with eGFR in the KDIGO kidney framework.

Ultra-processed foods UPF

Industrially formulated foods that often contain refined ingredients, additives, and little intact whole food.

In this system: Used as part of the dietary-pattern assessment, not as a stand-alone diagnosis.
V

VO₂max Maximal Oxygen Uptake

The maximum amount of oxygen the body can use during intense exercise. It reflects the combined performance of the heart, lungs, circulation, and muscles.

In this system: A major measure of aerobic reserve.

VO₂peak Peak Oxygen Uptake

The highest oxygen uptake reached during an exercise test when a true physiological maximum cannot be confirmed.

In this system: Often used similarly to VO₂max for functional assessment, with appropriate context.
W

Waist-to-height ratio WHtR

Waist circumference divided by height using the same units.

In this system: A simple measure of central body-size distribution and metabolic risk context.
Z

Z-score

A bone-density result comparing a person with others of the same age and sex.

In this system: Generally preferred over T-score in younger adults for bone-density interpretation.

Epigenetic reprogramming

An experimental approach that attempts to reset patterns of gene regulation associated with cellular aging while preserving cell identity.

In this system: Discussed only in the research/experimental layer; it does not affect the healthspan score.

Fasting-mimicking diet FMD

A multi-day, low-calorie eating pattern designed to reproduce some biological responses to fasting while still providing limited food.

In this system: Presented as a Valter Longo research strategy, not a core recommendation for all users.

IGF-1 Insulin-like Growth Factor 1

A hormone involved in growth, tissue repair, and nutrient signaling. Its effects depend on age, health, and physiological context.

In this system: May be discussed in nutrition/aging research but is not directly scored.

mTOR Mechanistic Target of Rapamycin

A cellular signaling pathway that responds to nutrients, energy, and growth signals and helps regulate growth and protein synthesis.

In this system: Relevant to aging biology research; it is not a user-facing treatment target in the core system.

NAD+ Nicotinamide Adenine Dinucleotide

A molecule required for cellular energy metabolism and many enzyme reactions, including reactions involving DNA repair and sirtuins.

In this system: Appears in the experimental molecular-aging education layer, not the core score.

NMN Nicotinamide Mononucleotide

A precursor the body can use to make NAD+. NMN is being studied as a possible way to influence age-related biology.

In this system: No core longevity points are awarded for using NMN.

Rapamycin

A prescription drug that inhibits mTOR and is used clinically for specific medical indications. It is also being studied in aging research.

In this system: Classified as experimental for healthy-aging use; the system never recommends self-prescribing it.

Senolytics

Experimental compounds intended to selectively remove senescent cells—cells that have stopped dividing and may produce inflammatory signals.

In this system: Research-stage longevity strategy; not part of the core recommendation engine.

Sirtuins

A family of enzymes involved in cellular stress responses, metabolism, DNA regulation, and NAD+-dependent signaling.

In this system: Discussed mainly in relation to Sinclair’s molecular-aging research.

Time-restricted eating TRE

An eating pattern in which daily food intake is limited to a consistent time window, such as 8–12 hours.

In this system: May be useful for some people as a metabolic or behavioral tool, but it is not required for a strong healthspan score.
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