A
Actionability
How practical and realistic an action is for changing a health factor.
In this system: Used when the recommendation engine ranks what to address first.
Albuminuria
An abnormal amount of the protein albumin in urine. It can be a sign of kidney damage even when kidney filtration still looks normal.
In this system: UACR is the urine test used to estimate albuminuria. The result is interpreted with eGFR, kidney history, and whether the finding persists over time.
ApoB Apolipoprotein B
A protein found on atherogenic particles that can enter artery walls. ApoB is often used as an estimate of the number of cholesterol-carrying particles that can contribute to plaque.
In this system: Used as an advanced cardiovascular risk marker.
ASCVD Atherosclerotic Cardiovascular Disease
Heart and blood-vessel disease caused by plaque buildup in arteries, including heart attack, ischemic stroke, and peripheral artery disease.
In this system: Used to distinguish primary prevention from people who already have established cardiovascular disease.
Atherosclerosis
The buildup of cholesterol-rich plaque inside artery walls. Over time it can narrow arteries or trigger blood clots.
In this system: Central to cardiovascular-risk interpretation.
B
Biological age
An estimate of how old the body appears biologically rather than by calendar age. This system intentionally does not calculate a biological age because current methods can create misleading precision.
In this system: Not used as a score in this system.
Blood pressure BP
The force of blood against artery walls. It is reported as systolic pressure over diastolic pressure, for example 120/80 mmHg.
In this system: A major cardiovascular-control measure.
Body Mass Index BMI
Weight in kilograms divided by height in meters squared. BMI is a rough body-size measure and does not directly measure body fat or muscle.
In this system: Used only as supporting body-composition context.
C
CAC Coronary Artery Calcium score
A CT-based score that measures calcified plaque in the coronary arteries. A higher score usually indicates more coronary atherosclerosis.
In this system: Used as cardiovascular risk context rather than a lifestyle score.
Chair-rise test Five-chair-rise / 5×STS
A functional test that measures how quickly a person can stand up from a chair five times without using the arms if possible.
In this system: Used to assess lower-body strength and functional reserve.
CKD Chronic Kidney Disease
Persistent abnormalities in kidney structure or function, usually present for at least three months.
In this system: The system avoids diagnosing CKD from a single abnormal value.
Clinical flag
A result that may deserve medical attention and is kept separate from ordinary healthspan scoring.
In this system: Clinical flags cannot be averaged away by strong results in other domains.
Clinical-first action
A recommendation that deserves medical follow-up before lifestyle optimization or experimental longevity strategies.
In this system: Highest priority lane in the recommendation engine.
Confidence / input support
A rule-based description of the amount and type of input supporting this result. It is not a statistical certainty or a measure of clinical validation.
In this system: Measured inputs, estimates, missing information, and reference applicability have different limits. Input support does not prove that a custom score predicts health outcomes.
Coverage
How much of the important information for a domain has been supplied.
In this system: Missing data lower coverage, not the health score.
CPET Cardiopulmonary Exercise Testing
A supervised exercise test that directly measures oxygen use, carbon dioxide production, breathing, and cardiovascular response during increasing effort.
In this system: The most direct method for measuring VO₂max or VO₂peak.
D
DASH Dietary Approaches to Stop Hypertension
An eating pattern rich in vegetables, fruits, whole grains, legumes, nuts, and appropriate low-fat foods, with lower sodium and limited highly processed foods.
In this system: A strongly supported dietary approach for blood-pressure control.
DBP Diastolic Blood Pressure
The lower blood-pressure number. It reflects arterial pressure while the heart relaxes between beats.
In this system: Used together with systolic blood pressure.
DXA Dual-energy X-ray Absorptiometry
A low-radiation scan commonly used to measure bone mineral density and help assess osteoporosis risk.
In this system: Used in the Bone & Fracture Resilience section.
E
eGFR Estimated Glomerular Filtration Rate
An estimate of how well the kidneys filter blood. It is usually calculated from blood creatinine plus age and sometimes other variables.
In this system: Interpreted together with UACR rather than alone.
Evidence grade
A simple label describing how strong the supporting evidence is. In this system, A is strongest, B is good human/guideline support, and C is more limited or indirect.
In this system: Shown on recommendations.
EWGSOP2 European Working Group on Sarcopenia in Older People 2
A European expert consensus framework for identifying and assessing sarcopenia, especially low muscle strength and function in older adults.
In this system: Provides screening anchors for grip strength and chair-rise performance.
F
Fasting glucose
Blood glucose measured after an overnight fast, typically at least 8 hours without caloric intake.
In this system: Used when HbA1c is unavailable or as additional metabolic context.
Fragility fracture
A fracture caused by a low level of trauma that would not normally break healthy bone, such as a fall from standing height.
In this system: An important signal of possible osteoporosis or increased fracture risk.
FRAX Fracture Risk Assessment Tool
A tool that estimates a person's 10-year probability of major osteoporotic fracture and hip fracture using clinical risk factors, sometimes with bone-density data.
In this system: Not currently embedded in the system because implementation/licensing needs to be handled separately.
FRIEND Fitness Registry and the Importance of Exercise National Database
A large reference database used to compare cardiorespiratory fitness values such as VO₂max across age and sex groups.
In this system: Used for VO₂max peer-percentile interpretation.
G
Grip strength
The maximum force produced when squeezing a hand dynamometer.
In this system: A practical measure of muscle strength and functional reserve.
H
HbA1c Hemoglobin A1c
A blood test that reflects average blood glucose exposure over roughly the previous 2–3 months.
In this system: Used for metabolic-health assessment and diabetes-range screening.
HDL-C High-Density Lipoprotein Cholesterol
The amount of cholesterol carried in HDL particles. HDL-C is part of standard lipid testing, but a higher value is not treated as a stand-alone longevity bonus.
In this system: Used mainly as cardiovascular context.
Health gap
The difference between a domain's current status and the system's high-reserve reference range.
In this system: Used internally when ranking recommendations.
Healthspan
The portion of life spent in good health and able to function independently, rather than simply the number of years lived.
In this system: The central outcome this system is designed around.
I
Intrinsic capacity
A World Health Organization concept describing the combined physical and mental capacities a person can draw on, including cognition, sensory function, psychological capacity, vitality, and locomotion.
In this system: Used to broaden the system beyond laboratory risk factors.
K
KDIGO Kidney Disease: Improving Global Outcomes
An international organization that publishes evidence-based guidelines for kidney disease.
In this system: Its eGFR × albuminuria framework is used in the kidney module.
L
LDL-C Low-Density Lipoprotein Cholesterol
The amount of cholesterol carried in LDL particles. Higher levels generally increase atherosclerotic cardiovascular risk.
In this system: A main cardiovascular-control variable.
Lean mass
Body mass that is not fat, including muscle, organs, water, and bone components.
In this system: Used only as supporting body-composition context because devices differ in accuracy.
Longevity
Length of life. Longevity is not identical to healthspan; living longer does not necessarily mean living longer in good function.
In this system: The system emphasizes healthspan and functional reserve rather than lifespan prediction.
Lp(a) Lipoprotein(a)
A cholesterol-carrying particle largely determined by genetics. High levels can raise cardiovascular risk independently of LDL-C.
In this system: Treated as an inherited risk enhancer, not as a lifestyle failure.
M
Metabolic health
How well the body regulates glucose, insulin-related processes, lipids, body composition, and energy balance.
In this system: Represented mainly through HbA1c/glucose and related context.
mmHg Millimeters of mercury
The standard unit used to report blood pressure.
In this system: For example, 120/80 mmHg.
Moderate-equivalent minutes
A way to combine moderate and vigorous exercise into one activity estimate. In this system, one vigorous minute counts approximately like two moderate minutes.
In this system: Used only when direct aerobic-fitness measurements are unavailable.
N
nmol/L Nanomoles per liter
A concentration unit used by some laboratories, including for Lp(a).
In this system: Lp(a) values in nmol/L are not automatically converted to mg/dL because the relationship is not fixed.
Non-HDL cholesterol Non-HDL-C
Total cholesterol minus HDL-C. It represents cholesterol carried by all potentially atherogenic particles.
In this system: Used as supporting cardiovascular context.
O
Osteopenia
A bone-density level lower than normal but not in the osteoporosis range when T-score criteria are appropriate.
In this system: May indicate increased fracture risk depending on the broader clinical context.
Osteoporosis
A condition of reduced bone strength that increases fracture risk. In appropriate populations, a DXA T-score of −2.5 or lower is in the osteoporosis range.
In this system: Bone interpretation depends on age, sex, menopausal status, fracture history, and other factors.
P
Percentile
A comparison with a reference population. For example, the 75th percentile means the result is higher or better than about 75% of the reference group when higher values indicate better performance.
In this system: Used for VO₂max, grip strength, and chair-rise reference comparisons where the published reference and test method apply.
PREVENT Predicting Risk of Cardiovascular Disease Events
An American Heart Association risk framework that estimates future cardiovascular risk in adults without established cardiovascular disease.
In this system: This system can accept an externally obtained PREVENT result but does not calculate it internally.
Primary prevention
Preventing a first cardiovascular event in a person who has not already had established atherosclerotic cardiovascular disease.
In this system: PREVENT applies to primary-prevention settings.
Protein g/kg/day
Daily protein intake expressed as grams of protein per kilogram of body weight per day.
In this system: Used to judge protein adequacy more fairly across different body sizes.
R
Reserve Physiological reserve
Extra functional capacity beyond what is needed for ordinary daily life. Higher reserve can help a person tolerate illness, injury, surgery, or aging-related stress.
In this system: A core concept behind Aerobic, Strength, and Mobility domains.
Resting heart rate RHR
Heart rate measured while resting and relaxed.
In this system: Used as supporting cardiovascular context rather than a dominant score.
S
Sarcopenia
Age-related loss of muscle strength and muscle quantity or quality that can impair physical function.
In this system: The system screens for low strength but does not diagnose sarcopenia.
SBP Systolic Blood Pressure
The upper blood-pressure number. It reflects arterial pressure when the heart contracts.
In this system: Used together with diastolic blood pressure.
Secondary prevention
Preventing additional cardiovascular events in someone who already has established cardiovascular disease.
In this system: Handled differently from primary prevention.
Sedentary time
Time spent sitting or otherwise awake with very low energy expenditure.
In this system: Used as lifestyle context; it does not replace direct fitness measurement.
STEADI Stopping Elderly Accidents, Deaths & Injuries
A CDC fall-prevention framework for screening and reducing fall risk in older adults.
In this system: Provides practical mobility and fall-risk screening anchors.
T
T-score
A bone-density result comparing a person's bone mineral density with that of a healthy young adult reference population.
In this system: Used mainly in postmenopausal women and men age 50 or older.
Triglycerides TG
A type of fat carried in the blood. Very high levels can raise pancreatitis risk and often reflect metabolic or dietary factors.
In this system: Used in cardiovascular/metabolic risk interpretation.
TUG Timed Up and Go
A mobility test in which a person stands from a chair, walks about 3 meters (10 feet), turns, walks back, and sits down while the total time is measured.
In this system: Used for mobility and fall-risk screening.
U
UACR Urine Albumin-to-Creatinine Ratio
A urine test that compares the protein albumin with creatinine. It can reveal signs of kidney damage even when kidney filtration still appears normal.
In this system: Interpreted together with eGFR and known kidney history. One abnormal result alone does not diagnose chronic kidney disease.
Ultra-processed foods UPF
Industrially formulated foods that often contain refined ingredients, additives, and little intact whole food.
In this system: Used as part of the dietary-pattern assessment, not as a stand-alone diagnosis.
V
VO₂max Maximal Oxygen Uptake
The maximum amount of oxygen the body can use during intense exercise. It reflects the combined performance of the heart, lungs, circulation, and muscles.
In this system: A major measure of aerobic reserve.
VO₂peak Peak Oxygen Uptake
The highest oxygen uptake reached during an exercise test when a true physiological maximum cannot be confirmed.
In this system: Often used similarly to VO₂max for functional assessment, with appropriate context.
W
Waist-to-height ratio WHtR
Waist circumference divided by height using the same units.
In this system: A simple measure of central body-size distribution and metabolic risk context.
Z
Z-score
A bone-density result comparing a person with others of the same age and sex.
In this system: Generally preferred over T-score in younger adults for bone-density interpretation.
Epigenetic reprogramming
An experimental approach that attempts to reset patterns of gene regulation associated with cellular aging while preserving cell identity.
In this system: Discussed only in the research/experimental layer; it does not affect the healthspan score.
Fasting-mimicking diet FMD
A multi-day, low-calorie eating pattern designed to reproduce some biological responses to fasting while still providing limited food.
In this system: Presented as a Valter Longo research strategy, not a core recommendation for all users.
IGF-1 Insulin-like Growth Factor 1
A hormone involved in growth, tissue repair, and nutrient signaling. Its effects depend on age, health, and physiological context.
In this system: May be discussed in nutrition/aging research but is not directly scored.
mTOR Mechanistic Target of Rapamycin
A cellular signaling pathway that responds to nutrients, energy, and growth signals and helps regulate growth and protein synthesis.
In this system: Relevant to aging biology research; it is not a user-facing treatment target in the core system.
NAD+ Nicotinamide Adenine Dinucleotide
A molecule required for cellular energy metabolism and many enzyme reactions, including reactions involving DNA repair and sirtuins.
In this system: Appears in the experimental molecular-aging education layer, not the core score.
NMN Nicotinamide Mononucleotide
A precursor the body can use to make NAD+. NMN is being studied as a possible way to influence age-related biology.
In this system: No core longevity points are awarded for using NMN.
Rapamycin
A prescription drug that inhibits mTOR and is used clinically for specific medical indications. It is also being studied in aging research.
In this system: Classified as experimental for healthy-aging use; the system never recommends self-prescribing it.
Senolytics
Experimental compounds intended to selectively remove senescent cells—cells that have stopped dividing and may produce inflammatory signals.
In this system: Research-stage longevity strategy; not part of the core recommendation engine.
Sirtuins
A family of enzymes involved in cellular stress responses, metabolism, DNA regulation, and NAD+-dependent signaling.
In this system: Discussed mainly in relation to Sinclair’s molecular-aging research.
Time-restricted eating TRE
An eating pattern in which daily food intake is limited to a consistent time window, such as 8–12 hours.
In this system: May be useful for some people as a metabolic or behavioral tool, but it is not required for a strong healthspan score.
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