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Understand your healthspan reserve. See what is strong, what deserves attention, and which changes have the best evidence for supporting healthy aging.
Enter ordinary health and performance data. The system separates disease-risk control, physical reserve, and intrinsic capacity without producing a misleading “biological age.”
Your current System record exists only in this browser.
Complete the short first step and see useful results immediately. Add labs or performance measurements later only if you want more precision.
Basic health context, blood pressure, activity, strength training, smoking, and sleep. About 3 minutes.
Get preliminary disease-risk control and physical-reserve results. Missing information is shown as uncertainty—not as poor health.
Add bloodwork, VO₂max, grip strength, mobility tests, bone, cognition, sensory, or social information whenever you have it.
The browser copy makes the System work quickly. An independent backup file gives you a way to recover assessments, snapshots, and Action Plan history if browser data is removed.
Checking the current record…
Browser data can be lost when cookies or site data are cleared.
Choose where to create HLI-System-Backup.json. While this System is open and file permission remains active, important changes are written to that file after they are saved in the System.
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Download creates a dated copy. Restore checks the file first, shows what it contains, and asks before replacing anything in this browser.
The backup contains health information and is not encrypted. The prototype does not upload it. Store it in a location you control and do not share it unless you intend to.
Clearing cookies or site data can remove the working copy held by this browser. It does not delete a backup file already saved on your computer. Clearing only cached images and files should not be used as a data-management step; use a hard refresh when updated System files need to reload.
The independent file includes current assessment entries, saved snapshots, the active Action Plan, selected route, route-specific records, notes, milestones, reviews, and archived cycles. Restoring it never changes the System’s calculation rules.
About 3 minutes. Answer what you know; leave anything else blank.
A single reading cannot establish a usual pattern. Keep the original readings for appropriate review.
Optional. Add only values you already know from recent blood or urine tests.
The units printed beside each field are the units used by this version. These are common U.S. reporting units. HbA1c accepts either % or mmol/mol; select the unit printed on the report. eGFR usually needs no conversion. Lp(a) already accepts either nmol/L or mg/dL.
This converter only changes reporting units. It does not decide whether a result is healthy. Laboratory methods and reference intervals can differ.
Leave blank if unknown. Use the sample date, not the day you entered it here.
Choose the report unit for the number you enter. Changing this choice does not convert the number in the box.
For example, a recent transfusion or a condition affecting red blood cells. Do not decide this from ancestry alone.
Leave blank if unknown. Use the sample date, not the day you entered it here.
Leave blank if unknown. Use the sample date, not the day you entered it here.
This answer does not diagnose chronic kidney disease or change a score.
Leave blank if unknown. Use the sample date, not the day you entered it here.
A non-fasting value is retained as context. Fasting screening thresholds are used only when fasting is confirmed.
Leave blank if unknown. Use the sample date, not the day you entered it here.
Performance data outrank behavior proxies. VO₂max, grip strength, and five-chair-rise can now be translated automatically into age/sex reference percentiles when the published reference population and test method apply.
Open the areas you want to review. Missing answers remain unknown; each result explains whether it has enough information for its stated interpretation.
The estimate needs actual sleep duration (entered in Quick Assessment; note naps separately in your diary), restorative quality and awakening frequency. Daytime effects and symptoms guide the next step. Leave observations you cannot know, such as unobserved breathing pauses, unknown.
Use a typical two-week period for meals. All three food-pattern answers are needed for a numerical estimate. The questions about eating, access and weight help decide what to do next; no blood test or exact protein count is required to complete the food-pattern review.
Use your recent experience, usually the past two weeks. These questions do not diagnose depression or measure personal worth. You can skip any question. Nobody monitors these answers.
No single longevity score. Important weaknesses remain visible even when other areas are strong.
Turn the priorities in this profile into one manageable first step, something useful to track, and a clear point for review.
Coverage describes selected entered data, with product-defined weights. It does not measure accuracy, health or clinical certainty. Even 100% coverage can coexist with Verify or Clinical follow-up when dates, test context, applicability or safety need attention.
Direct peer comparisons are shown only where a validated reference is embedded. TUG remains an age-context benchmark rather than a percentile.
Missing measurements are ranked by how much they would improve confidence—not treated as health deficits.
Choose one realistic focus, take the first step, and return to review what changed. Important safety and professional follow-up priorities remain visible.
Results describe every domain; this panel lists supported next steps. A Verify direction can mean checking a named entry in Data Input. It does not automatically generate a separate plan. Your chosen focus stays active unless you switch it; safety and professional follow-up remain visible.
The six stages are one guided journey—not six separate assignments. The first three stages explain the concern, check the relevant safety limits, and choose the right route. Stage 4 may be a lifestyle action, an observation, a professional follow-up step, or an urgent safety action. Stage 5 reviews what happened or what became clearer. Stage 6 helps you decide what comes next.
Stage 4 is not always a seven-day checklist. The record matches the plan. Sleep uses nights. Aerobic, strength, and balance plans use sessions. Nutrition uses food or meal records. Social connection uses milestones. Blood-pressure plans record actual morning and evening averages. Clinical pathways use status or the specific information needed for follow-up.
You can preview every stage before starting. Later steps remain flexible because your experience, safety, and new health information may change the best route.
Start with one clear step. Keep the other priorities in view.
Clinical issues come first. A finding that deserves medical follow-up cannot be pushed down the page by strong fitness, diet, or other good results.
Evidence matters. Strong guideline-supported actions rank above experimental longevity ideas.
Ranking is a guide to attention. It is a product decision based on the entered information, not a prediction of which action will benefit you most. Your chosen Action Plan can remain different from the first recommendation.
Missing information is not a failure. It can limit what the System can assess; it is not scored as poor health.
No medication instructions. This tool never tells you to start, stop, or change prescription medication; those decisions are routed to clinician discussion.
Evidence key: A = strong guideline/intervention evidence; B = good human evidence/guideline support; C = useful but less certain evidence.
Explore how a few realistic changes would alter your current healthspan profile. This is a hypothetical comparison—not a prediction of lifespan or biological age.
The System will explain what changes, why it changes, and whether your weakest-link priorities move.
Save dated assessments and follow measured values and domain status over time. Trends are descriptive; they do not estimate biological aging rate.
The chart uses snapshot dates; measurement dates are listed below. Missing values break the line. A new snapshot of an old report is not a new measurement.
| Snapshot saved | Selected metric | Measured / reported | Flags | Action |
|---|
Choose a question. Explore the information behind it, then connect it to a practical next step.
Blood pressure, atherogenic lipids, nicotine exposure, and established vascular disease shape the long-term risk of heart attack, stroke, heart failure, and vascular damage.
Keep blood pressure and atherogenic cholesterol appropriately controlled and avoid tobacco/nicotine exposure.
HbA1c describes a longer glucose-exposure window; a glucose reading describes a particular time. HbA1c does not require fasting. A separate glucose value needs confirmed fasting before fasting screening bands are applied.
The display uses a usable HbA1c unless confirmed-fasting glucose shows a higher screening concern. A lower result does not cancel a higher concern. An unusable second marker does not erase the usable first one.
Kidney filtration and urine albumin provide different information. Interpret eGFR together with UACR; an abnormal available result deserves appropriate follow-up even when the other result is missing.
The displayed KDIGO-style category does not establish how long an abnormality has been present or diagnose chronic kidney disease from one result. The number out of 100 is a custom display mapping, not a measured percentage of kidney health.
VO₂max reflects the integrated ability of the heart, lungs, circulation, and muscles to deliver and use oxygen during demanding activity.
Regular aerobic activity builds capacity; direct VO₂ measurement provides capacity information that exercise minutes alone cannot establish. This version embeds FRIEND 2015 treadmill references; cycle tests and estimates remain visible without a treadmill percentile.
Strength supports independence, glucose disposal, mobility, recovery from illness, and the ability to keep performing daily tasks as reserve declines with age.
Progressive resistance training plus adequate nutrition. Grip and chair-rise values use reference percentiles only when the age, sex and test method apply. The displayed composite is a custom score, not a validated diagnosis. A low strength screen or unsafe test attempt has its own assessment route.
Mobility and balance determine whether physical reserve can be used safely. Bone resilience matters because a single serious fracture can sharply reduce independence.
Strength, balance practice, safe mobility, fall prevention, vision/footwear review when relevant, and appropriate bone assessment.
Fracture history, falls, medicines and an appropriately interpreted bone-density report help establish the next step. An absent DXA result is not a zero score, and no reported fracture does not measure bone strength.
The usefulness of a T-score or Z-score depends on age, menopause and the measurement site. Keep the full report and seek interpretation when needed; do not arrange a scan solely to complete this display.
BMI describes body size. Waist-to-height ratio adds context about central adiposity when BMI is below 35. Neither directly measures fat or muscle.
A waist-to-height ratio from 0.5 to below 0.6 suggests increased central adiposity; 0.6 or above suggests a higher level. These bands do not set an individual weight-loss target. Interpret BMI cautiously in older or muscular adults, and use appropriate guidance during pregnancy, significant swelling or other limitations.
Measure consistently, consider metabolic health, strength, function and weight trend, and choose a next step only when the context supports it.
Describe actual sleep during your main sleep period, how restorative it feels, awakenings and next-day function. Use the same typical two-week period. A wearable estimate or a diary can help recall; neither diagnoses a sleep disorder.
Duration, quality and awakenings feed a custom, unvalidated numerical estimate. One answer cannot describe the whole domain. Longer sleep is interpreted in context. A high score does not rule out breathing problems or other disorders.
Next step: Maintain a workable favorable pattern; Verify missing information; Improve a supported gap; seek Clinical follow-up for breathing pauses, marked sleepiness or a persistent impairing problem. Unknown partner observations may stay unknown.
The Sleep pathway offers a short diary, a relevant experiment or clinical discussion. Seven nights is an observation window, not a promised recovery time. Persistent insomnia may need CBT-I; sleep-hygiene tips alone are not its recommended treatment. Do not extend time in bed indefinitely or start unsupervised sleep restriction.
Usual meals, enough intake, eating ability, food access and unintended weight change matter together. A food-pattern score cannot show whether every nutrient is adequate or diagnose malnutrition.
The custom estimate requires all three food-pattern answers. Protein is an optional component when age, body size and clinical context allow a general comparison. Reaching that reference earns no further points for taking more. Days-per-week cues and numerical weights are product conventions, not validated clinical thresholds.
Next step: A favorable complete picture can say Maintain despite Moderate confidence in self-reported food amounts. Missing important context says Verify. A specific suitable food or access gap can say Improve. Eating difficulty, prolonged low intake or significant unplanned weight loss needs assessment before ordinary meal optimization.
The Nutrition review asks what you eat, what makes it difficult, which support is needed and when you will review it. Saved notes reappear at review; they do not change scores. Existing nutrition advice takes priority. Fasting-window length is context only; it earns no points.
These categories describe reported concerns and care needs. They do not measure cognition, hearing acuity, visual acuity or mental health, and are not a validated WHO ICOPE assessment.
A single concern about memory, thinking or a new task difficulty can justify a healthcare discussion. Sudden confusion needs emergency assessment. Existing care should be continued; an assessment is not repeated just to improve the display. Sleep, mood, medicines, language, hearing, vision and physical barriers can affect the history and testing.
No reported change does not prove normal cognition. Unknown answers remain unknown, and an unavailable outside observer is not recorded as a reassuring observation.
These categories describe reported concerns and care needs. They do not measure cognition, hearing acuity, visual acuity or mental health, and are not a validated WHO ICOPE assessment.
Answer for daily function with your usual aids or correction. Difficulty can remain stable despite appropriate treatment or rehabilitation; it should not automatically be called untreated. New sudden hearing change or a vision warning sign takes priority over an existing plan.
Maintain can mean continuing useful support for a stable limitation. It does not mean hearing or vision has become normal. Unanswered information about one sense is not supplied by the other.
These categories describe reported concerns and care needs. They do not measure cognition, hearing acuity, visual acuity or mental health, and are not a validated WHO ICOPE assessment.
Connection depends on your needs and available support, as well as contact frequency. Stress, purpose, mood and participation stay visible separately; one good answer cannot cancel a concern in another area. A physical disability or access barrier is not a psychological diagnosis.
Persistent mood symptoms or substantial daily difficulty leads to professional support. Immediate safety concerns lead to crisis or emergency help. Nobody monitors your answers. Brief questions and the product's stress/purpose prompts are not diagnostic scales.
The connection plan asks what contact would feel useful. The resilience review asks for a recent example, its effect, a chosen next step and a review plan. Use Save my records; the notes are displayed at review, never interpreted to change health scores.
Higher layers can be interesting, but they should never substitute for an unresolved problem lower in the pyramid.
Guidelines and/or substantial human outcome evidence. These actions can drive core recommendations.
Useful human evidence or strong professional guidance, but less definitive than Grade A.
Promising or indirect evidence. May educate, but should not displace stronger actions.
Mechanistically interesting or early clinical research; not part of the core healthspan score.
These viewpoints can help readers understand the field. They do not determine the system’s score.
Attia strongly emphasizes cardiorespiratory fitness, strength, stability, metabolic health, and aggressive prevention of chronic disease.
His framework asks people to build enough reserve today to preserve the physical abilities they want in later decades.
Longo emphasizes plant-forward dietary patterns, nutrient-sensing pathways, avoidance of chronic overnutrition, and research on fasting and the fasting-mimicking diet (FMD).
His work highlights the tension between growth signaling earlier in life and preserving lean tissue and resilience later in life.
Sinclair’s laboratory investigates cellular aging mechanisms including NAD+ biology, sirtuins, mitochondrial signaling, and epigenetic loss of cellular identity.
This research has helped make molecular aging interventions a major scientific field.
This educational system describes separate health domains. It does not diagnose a condition, calculate biological age or predict years of life. The custom scores, directions and recommendation ranking have not been clinically validated as a combined system.
A number out of 100 is a display convention. Measured means that an entered value comes from a test or measurement; the System does not verify the report or its accuracy. Estimated and categorical results have different limits. A favorable self-report does not establish normal clinical function.
Confidence describes rule-based input support, not statistical certainty. Coverage counts selected entries with product-defined weights, not completeness of medical assessment. Neither establishes that a custom score predicts health outcomes.
| Current direction | Practical meaning |
|---|---|
| Maintain | Continue a supported favorable pattern or useful existing care. This does not mean no health risk. |
| Verify | Clarify the specific missing or uncertain information. Add available evidence in Data Input; a new test or habit is not automatically required. |
| Improve | The entered information identifies a modifiable concern. The next step may be an observation or review before choosing a particular habit. |
| Clinical follow-up | A safety or care finding takes priority over ordinary optimization. Urgency comes from the specific message, not the color or score. |
Heart & Vessels describes current BP, LDL-C and nicotine control. It is not total cardiovascular risk; prior disease, Lp(a), CAC, treatment and other context remain separate. Major uncontrolled factors and explicit clinical findings cannot be hidden by favorable components.
Glucose markers are checked separately. HbA1c does not require fasting. Usable HbA1c is preferred unless confirmed-fasting glucose has a higher screening band; a lower result does not cancel a concerning one. Missing context for a second marker does not erase the first. Known diabetes and qualifying high or low results need individualized interpretation instead of a general-reference score.
Kidney interpretation uses eGFR together with UACR. A missing partner result cannot cancel an abnormal available marker. A single pair does not establish chronicity or diagnose CKD; the score is a custom mapping of the category.
Physical comparisons require an applicable age, sex reference and test protocol. A measured VO₂ result is not replaced by an activity proxy when reference comparison is unavailable. Bone density and body size remain contextual. Sleep and nutrition scores are self-report estimates; cognition, sensory function and psychological/social context remain categorical.
Recommendations follow explicit safety findings and supported gaps in the entered profile. Their ranking is a product rule, not a prediction of personal benefit. The Action Plan keeps one chosen focus while retaining relevant clinical and information tasks. Verify may simply mean checking a named field; not every domain needs a separate plan.
Stages 1–3 explain the reason, review safety and select a route. Stage 4 records the chosen step; Stage 5 reviews the saved information; Stage 6 chooses what follows. Back and Next allow review without recording completion. Use Save my records or Save review to commit entries. Switching focus preserves saved progress. Empty cycles are excluded from recovery history.
Notes are shown back to you at review. The System does not analyze the writing, prove benefit from a check-in or increase a health score because a task was completed. Plan-review dates and measurement/outcome timing are separate.
Expected reach describes areas an action may support. What If recalculates only explicitly modeled inputs in a temporary scenario; it does not infer that better sleep or walking changed your glucose, kidney results or another unmeasured outcome. Invalid targets block calculation, and actual clinical guidance remains in force.
Trends compares saved entries. Score changes are descriptive, not validated measures of clinical improvement. The 1-point grouping is a display convention. Snapshot dates and measurement dates are different; unknown dates, changed methods, new input sources or changed rule versions can prevent comparison. Missing points break the chart line. Observed changes together do not establish a common cause.
Assessment fields save in this browser. Action records require explicit saving. Data & Backup can export and restore assessment entries, snapshots and saved plans. A supported browser may also update a user-selected local backup file. The prototype does not upload those records or provide account synchronization. The recovery file contains unencrypted health information.
The evidence framework includes ACC/AHA cardiovascular guidance, ADA diabetes guidance, KDIGO kidney guidance, physical-function references, HHS activity guidance, CDC STEADI, osteoporosis/bone-density guidance, ESPEN nutrition guidance and cognitive, sensory and psychosocial care resources. Recommendations include their relevant source links. Guideline support for a measurement or action does not validate this product's custom scoring or ranking.
The embedded FRIEND 2015 values were cross-checked against all 84 FRIEND cells reproduced in Rossi Neto et al. (2019), Table 2. The original registry population and treadmill protocol still limit applicability; this is not a switch to newer reference standards.
| Module | Primary basis | Current use |
|---|---|---|
| VO₂ | FRIEND treadmill CPET reference standards | Direct treadmill CPET only; approximate percentile, age 20–79 |
| Kidney | KDIGO GFR × albuminuria framework | Joint risk stratum |
| Grip strength | iGRIPS / Tomkinson et al. 2025 | Confirmed protocol and applicable age/sex percentile; separate older-adult EWGSOP2 screen |
| Chair rise | Grgic et al. pooled FTSST norms | Confirmed protocol and applicable age/sex percentile; separate older-adult EWGSOP2 screen |
| TUG / falls | Bohannon age benchmarks + CDC STEADI | Age-context benchmark + safety signals; no invented percentile |
| Unified functional norms | CLSA / Mayhew et al. | Future harmonization option |
The System does not perform a formal cognitive test, a psychiatric diagnostic scale, FRAX or its own PREVENT calculation. An externally obtained PREVENT result needs compatible context. Unified physical reference sets, causal attribution across domains, drug prescribing and experimental longevity treatments are outside the current model.
Plain-language explanations of the medical, scientific, and technical terms used throughout the Healthspan & Longevity Intelligence System.
How practical and realistic an action is for changing a health factor.
An abnormal amount of the protein albumin in urine. It can be a sign of kidney damage even when kidney filtration still looks normal.
A protein found on atherogenic particles that can enter artery walls. ApoB is often used as an estimate of the number of cholesterol-carrying particles that can contribute to plaque.
Heart and blood-vessel disease caused by plaque buildup in arteries, including heart attack, ischemic stroke, and peripheral artery disease.
The buildup of cholesterol-rich plaque inside artery walls. Over time it can narrow arteries or trigger blood clots.
An estimate of how old the body appears biologically rather than by calendar age. This system intentionally does not calculate a biological age because current methods can create misleading precision.
The force of blood against artery walls. It is reported as systolic pressure over diastolic pressure, for example 120/80 mmHg.
Weight in kilograms divided by height in meters squared. BMI is a rough body-size measure and does not directly measure body fat or muscle.
A CT-based score that measures calcified plaque in the coronary arteries. A higher score usually indicates more coronary atherosclerosis.
A functional test that measures how quickly a person can stand up from a chair five times without using the arms if possible.
Persistent abnormalities in kidney structure or function, usually present for at least three months.
A result that may deserve medical attention and is kept separate from ordinary healthspan scoring.
A recommendation that deserves medical follow-up before lifestyle optimization or experimental longevity strategies.
A rule-based description of the amount and type of input supporting this result. It is not a statistical certainty or a measure of clinical validation.
How much of the important information for a domain has been supplied.
A supervised exercise test that directly measures oxygen use, carbon dioxide production, breathing, and cardiovascular response during increasing effort.
An eating pattern rich in vegetables, fruits, whole grains, legumes, nuts, and appropriate low-fat foods, with lower sodium and limited highly processed foods.
The lower blood-pressure number. It reflects arterial pressure while the heart relaxes between beats.
A low-radiation scan commonly used to measure bone mineral density and help assess osteoporosis risk.
An estimate of how well the kidneys filter blood. It is usually calculated from blood creatinine plus age and sometimes other variables.
A simple label describing how strong the supporting evidence is. In this system, A is strongest, B is good human/guideline support, and C is more limited or indirect.
A European expert consensus framework for identifying and assessing sarcopenia, especially low muscle strength and function in older adults.
Blood glucose measured after an overnight fast, typically at least 8 hours without caloric intake.
A fracture caused by a low level of trauma that would not normally break healthy bone, such as a fall from standing height.
A tool that estimates a person's 10-year probability of major osteoporotic fracture and hip fracture using clinical risk factors, sometimes with bone-density data.
A large reference database used to compare cardiorespiratory fitness values such as VO₂max across age and sex groups.
The maximum force produced when squeezing a hand dynamometer.
A blood test that reflects average blood glucose exposure over roughly the previous 2–3 months.
The amount of cholesterol carried in HDL particles. HDL-C is part of standard lipid testing, but a higher value is not treated as a stand-alone longevity bonus.
The difference between a domain's current status and the system's high-reserve reference range.
The portion of life spent in good health and able to function independently, rather than simply the number of years lived.
A World Health Organization concept describing the combined physical and mental capacities a person can draw on, including cognition, sensory function, psychological capacity, vitality, and locomotion.
An international organization that publishes evidence-based guidelines for kidney disease.
The amount of cholesterol carried in LDL particles. Higher levels generally increase atherosclerotic cardiovascular risk.
Body mass that is not fat, including muscle, organs, water, and bone components.
Length of life. Longevity is not identical to healthspan; living longer does not necessarily mean living longer in good function.
A cholesterol-carrying particle largely determined by genetics. High levels can raise cardiovascular risk independently of LDL-C.
How well the body regulates glucose, insulin-related processes, lipids, body composition, and energy balance.
The standard unit used to report blood pressure.
A way to combine moderate and vigorous exercise into one activity estimate. In this system, one vigorous minute counts approximately like two moderate minutes.
A concentration unit used by some laboratories, including for Lp(a).
Total cholesterol minus HDL-C. It represents cholesterol carried by all potentially atherogenic particles.
A bone-density level lower than normal but not in the osteoporosis range when T-score criteria are appropriate.
A condition of reduced bone strength that increases fracture risk. In appropriate populations, a DXA T-score of −2.5 or lower is in the osteoporosis range.
A comparison with a reference population. For example, the 75th percentile means the result is higher or better than about 75% of the reference group when higher values indicate better performance.
An American Heart Association risk framework that estimates future cardiovascular risk in adults without established cardiovascular disease.
Preventing a first cardiovascular event in a person who has not already had established atherosclerotic cardiovascular disease.
Daily protein intake expressed as grams of protein per kilogram of body weight per day.
Extra functional capacity beyond what is needed for ordinary daily life. Higher reserve can help a person tolerate illness, injury, surgery, or aging-related stress.
Heart rate measured while resting and relaxed.
Age-related loss of muscle strength and muscle quantity or quality that can impair physical function.
The upper blood-pressure number. It reflects arterial pressure when the heart contracts.
Preventing additional cardiovascular events in someone who already has established cardiovascular disease.
Time spent sitting or otherwise awake with very low energy expenditure.
A CDC fall-prevention framework for screening and reducing fall risk in older adults.
A bone-density result comparing a person's bone mineral density with that of a healthy young adult reference population.
A type of fat carried in the blood. Very high levels can raise pancreatitis risk and often reflect metabolic or dietary factors.
A mobility test in which a person stands from a chair, walks about 3 meters (10 feet), turns, walks back, and sits down while the total time is measured.
A urine test that compares the protein albumin with creatinine. It can reveal signs of kidney damage even when kidney filtration still appears normal.
Industrially formulated foods that often contain refined ingredients, additives, and little intact whole food.
The maximum amount of oxygen the body can use during intense exercise. It reflects the combined performance of the heart, lungs, circulation, and muscles.
The highest oxygen uptake reached during an exercise test when a true physiological maximum cannot be confirmed.
Waist circumference divided by height using the same units.
A bone-density result comparing a person with others of the same age and sex.
An experimental approach that attempts to reset patterns of gene regulation associated with cellular aging while preserving cell identity.
A multi-day, low-calorie eating pattern designed to reproduce some biological responses to fasting while still providing limited food.
A hormone involved in growth, tissue repair, and nutrient signaling. Its effects depend on age, health, and physiological context.
A cellular signaling pathway that responds to nutrients, energy, and growth signals and helps regulate growth and protein synthesis.
A molecule required for cellular energy metabolism and many enzyme reactions, including reactions involving DNA repair and sirtuins.
A precursor the body can use to make NAD+. NMN is being studied as a possible way to influence age-related biology.
A prescription drug that inhibits mTOR and is used clinically for specific medical indications. It is also being studied in aging research.
Experimental compounds intended to selectively remove senescent cells—cells that have stopped dividing and may produce inflammatory signals.
A family of enzymes involved in cellular stress responses, metabolism, DNA regulation, and NAD+-dependent signaling.
An eating pattern in which daily food intake is limited to a consistent time window, such as 8–12 hours.